At least 25 people have been killed in an attack launched by Pakistani separatists targeting a railway station in northwestern province of Baluchistan.

The blast on Saturday hit as passengers waited on a platform at the main railway station in the provincial capital Quetta.

"Fourteen army personnel are among the 25 confirmed dead," said Muhammad Baloch, a senior local police official.

A spokesperson for a local hospital said 46 people wounded in the blast had been brought to the facility, along with multiple dead.

The toll of Saturday's blast was particularly high for the southwestern province which is the target of frequent attacks.

Acting President Syed Yousaf Raza Gillani denounced the attack, calling the perpetrators "enemies of humanity," and emphasized the government's commitment to eliminate terrorism.

The attack was claimed by the Baloch Liberation Army (BLA), one of the area's main militant groups. The group frequently claims deadly attacks against security forces or Pakistanis from other provinces, notably Punjabis.

The resource-rich Balochistan province in Pakistan is a transit route, bordering Afghanistan to the north, and Iran to the west.